Methylated-DNA-protein-cysteine methyltransferase
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O6-alkylguanine DNA alkyltransferase AGT, is a protein that in humans is encoded by the MGMT gene.[5][6] MGMT is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents.[7] The two bacterial isozymes are Ada and Ogt.
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