Platelet-derived growth factor receptor
Cell surface receptors / From Wikipedia, the free encyclopedia
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Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer.[2] There are two forms of the PDGF-R, alpha and beta each encoded by a different gene.[3] Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.[4]
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Quick Facts Identifiers, Symbol ...
Platelet-derived growth factor receptor | |||||||||
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Identifiers | |||||||||
Symbol | PDGFR | ||||||||
Pfam | PF04692 | ||||||||
InterPro | IPR006782 | ||||||||
Membranome | 1204 | ||||||||
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Quick Facts Identifiers, Symbol ...
platelet-derived growth factor receptor, alpha polypeptide | |||||||
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Identifiers | |||||||
Symbol | PDGFRA | ||||||
NCBI gene | 5156 | ||||||
HGNC | 8803 | ||||||
OMIM | 173490 | ||||||
RefSeq | NM_006206 | ||||||
UniProt | P16234 | ||||||
Other data | |||||||
Locus | Chr. 4 q12 | ||||||
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Quick Facts Identifiers, Symbol ...
platelet-derived growth factor receptor, beta polypeptide | |||||||
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Identifiers | |||||||
Symbol | PDGFRB | ||||||
Alt. symbols | PDGFR | ||||||
NCBI gene | 5159 | ||||||
HGNC | 8804 | ||||||
OMIM | 173410 | ||||||
RefSeq | NM_002609 | ||||||
UniProt | P09619 | ||||||
Other data | |||||||
Locus | Chr. 5 q31-q32 | ||||||
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