User:Mr. Ibrahem/Buspirone
From Wikipedia, the free encyclopedia
Buspirone, sold under the brand name Buspar among others, is a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder.[9][10] Benefits support its short term use.[11] It has not been found to be effective in treating psychosis.[9] It is taken by mouth, and it may take up to four weeks for an effect.[9][10]
Clinical data | |
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Pronunciation | /ˈbjuːspɪroʊn/ (BEW-spi-rohn) |
Trade names | Buspar, Namanspin |
Other names | MJ 9022-1[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a688005 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 3.9%[2] |
Protein binding | 86–95%[3] |
Metabolism | Liver (via CYP3A4)[4][5] |
Metabolites | 5-OH-Buspirone; 6-OH-Buspirone; 8-OH-Buspirone; 1-PPTooltip 1-(2-pyrimidinyl)piperazine[6][7][8] |
Elimination half-life | 2.5 hours[4] |
Excretion | Urine: 29–63%[3] Feces: 18–38%[3] |
Identifiers | |
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Chemical and physical data | |
Formula | C21H31N5O2 |
Molar mass | 385.512 g·mol−1 |
3D model (JSmol) | |
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Common side effects include nausea, headaches, dizziness, and trouble concentrating.[9][11] Serious side effects may include hallucinations, serotonin syndrome, and seizures.[11] Use in pregnancy appears to be safe but has not been well studied, while use during breastfeeding is not recommended.[11][12] How it works is not clear but it is unrelated to benzodiazepines.[9]
Buspirone was first made in 1968 and approved for medical use in the United States in 1986.[9][10] It is available as a generic medication.[11] A month supply in the United Kingdom costs the NHS about £10 as of 2019.[11] In the United States the wholesale cost of this amount is about US$3.[13] In 2017, it was the 80th most commonly prescribed medication in the United States, with more than ten million prescriptions.[14][15]