User:Mr. Ibrahem/MDMA
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3,4-Methyl
Clinical data | |
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Pronunciation | methylenedioxymethamphetamine: /ˌmɛθɪliːndaɪˈɒksi/ /ˌmɛθæmˈfɛtəmiːn/ |
Other names | 3,4-MDMA; Ecstasy (E, X, XTC); Molly; Mandy[2][3] |
AHFS/Drugs.com | MDMA |
Dependence liability | Physical: not typical[4] Psychological: moderate |
Addiction liability | Low–moderate[5][6][7] |
Routes of administration | Common: by mouth[8] Uncommon: snorting,[8] inhalation (vaporization),[8] injection,[8][9] rectal |
Drug class | empathogen–entactogen stimulant |
Legal status | |
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Pharmacokinetic data | |
Metabolism | Liver, CYP450 extensively involved, including CYP2D6 |
Metabolites | MDA, HMMA, HMA, DHA, MDP2P, MDOH[10] |
Onset of action | 30–45 minutes (by mouth)[11] |
Elimination half-life | (R)-MDMA: 5.8 ± 2.2 hours (variable)[12] (S)-MDMA: 3.6 ± 0.9 hours (variable)[12] |
Duration of action | 4–6 hours[6][11] |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C11H15NO2 |
Molar mass | 193.246 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
Boiling point | 105 °C (221 °F) at 0.4 mmHg (experimental) |
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Adverse effects include addiction, memory problems, paranoia, difficulty sleeping, teeth grinding, blurred vision, sweating and a rapid heartbeat.[14] Deaths have been reported due to increased body temperature and dehydration.[14] Following use people often feel depressed and tired.[14] MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine and noradrenaline in parts of the brain.[14][15] It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.[8][16]
MDMA is illegal in most countries[14][17] and, as of 2018, has no approved medical uses.[8][18] Limited exceptions are sometimes made for research.[15] Researchers are investigating whether MDMA may assist in treating severe, treatment-resistant posttraumatic stress disorder (PTSD) with phase 3 clinical trials to look at effectiveness and safety expected to begin in 2018.[19] In 2017, the FDA granted MDMA a breakthrough therapy designation[note 2] for PTSD, meaning that if studies show promise, a review for potential medical use could occur more quickly.[23]
MDMA was first developed in 1912 by Merck.[24] It was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s.[14][15] MDMA is commonly associated with dance parties, raves, and electronic dance music.[25] It may be mixed with other substances such as ephedrine, amphetamine, and methamphetamine.[14] In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population).[26] This was broadly similar to the percentage of people who use cocaine or amphetamines, but lower than for cannabis or opioids.[26] In the United States, as of 2017, about 7% of people have used MDMA at some point in their lives and 0.9% have used it in the last year.[27]