Cardiac amyloidosis
Medical condition / From Wikipedia, the free encyclopedia
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Cardiac amyloidosis is a subcategory of amyloidosis where there is depositing of the protein amyloid in the cardiac muscle and surrounding tissues. Amyloid, a misfolded and insoluble protein, can become a deposit in the heart's atria, valves, or ventricles. These deposits can cause thickening of different sections of the heart, leading to decreased cardiac function.[1] The overall decrease in cardiac function leads to a plethora of symptoms.[2] This multisystem disease was often misdiagnosed, with a corrected analysis only during autopsy. Advancements of technologies have increased earlier accuracy of diagnosis. Cardiac amyloidosis has multiple sub-types including light chain, familial, and senile.[3] One of the most studied types is light chain cardiac amyloidosis.[2] Prognosis depends on the extent of the deposits in the body and the type of amyloidosis.[4] New treatment methods are actively being researched in regards to the treatment of heart failure and specific cardiac amyloidosis problems.[5][6]