Long-lived plasma cell
White blood cell / From Wikipedia, the free encyclopedia
Long-lived plasma cells (LLPCs) are a distinct subset of plasma cells that play a crucial role in maintaining humoral memory and long-term immunity.[1] They continuously produce and secrete high-affinity antibodies into the bloodstream, conversely to memory B cells, which are quiescent and respond quickly to antigens upon recall.[2]
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Initially, it was believed that memory B cells replenish LLPCs.[1] However, allergen-specific IgE production through bone marrow transplantation in non-allergic individuals suggests LLPCs may be long-lived. Allergies developed without antigenic re-stimulation.[2] That led to the understanding that LLPCs are long-lived cells, contributing to the sustained production of specific antibodies[3]