Mifepristone
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Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about a medical abortion during pregnancy and manage early miscarriage.[5] This combination is 97% effective during the first 63 days of pregnancy.[6] It is also effective in the second trimester of pregnancy.[7][8] It is taken by mouth.[5]
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Pronunciation | /ˌmɪfəˈprɪˌstoʊn/[1] |
Trade names | Mifegyne, Mifeprex, Korlym, others |
Other names | RU-486; RU-38486; ZK-98296; 11β-[p-(Dimethylamino)phenyl]-17α-(1-propynyl)estra-4,9-dien-17β-ol-3-one |
AHFS/Drugs.com | Monograph |
MedlinePlus | a600042 |
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Routes of administration | By mouth |
Drug class | Antiprogestogen; Antiglucocorticoid |
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Bioavailability | 69% |
Protein binding | 98% |
Metabolism | Liver |
Excretion | Feces: 83% urine: 9% |
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ECHA InfoCard | 100.127.911 |
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Formula | C29H35NO2 |
Molar mass | 429.604 g·mol−1 |
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Density | 1.189 g/cm3 |
Melting point | 194 °C (381 °F) |
Boiling point | 629 °C (1,164 °F) |
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The more common adverse effects include abdominal pain, feeling tired, and vaginal bleeding.[5] Serious side effects may include heavy vaginal bleeding, bacterial infection, and birth defects if the pregnancy does not end.[5] If used, appropriate follow-up care needs to be available.[5][9] Mifepristone is an antiprogestogen.[5] It works by blocking the effects of progesterone, making both the cervix and uterine vessels dilate and causing uterine contraction.[5]
Mifepristone was developed in 1980 and came into use in France in 1987.[10] It became available in the United States in 2000.[11][7] It is on the World Health Organization's List of Essential Medicines.[12][13] Mifepristone was approved in Canada in January 2017.[14][15]