PINK1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.[5][6]
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It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria.[7][8] PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation.[9] Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.[10]