Pancreatic enzymes (medication)
Amylase, lipase, and protease mixture / From Wikipedia, the free encyclopedia
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Pancreatic enzymes, also known as pancreases or pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, protease and lactase.[2][3] They are used to treat malabsorption syndrome due to certain pancreatic problems.[2] These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long term pancreatitis, pancreatic cancer, or MODY 5, among others.[2][4] The preparation is taken by mouth.[2]
This article is missing information about Lactase supplement. Why is lactase not included?. (January 2024) |
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Trade names | Creon, Pancreaze, Pertzye, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604035 |
Routes of administration | By mouth |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.053.309 |
Common side effects include vomiting, abdominal pain, constipation, and diarrhea.[2] Other side effects include perianal irritation and high blood uric acid.[4] The enzymes are from pigs.[4] Use is believed to be safe during pregnancy.[4] The components are digestive enzymes similar to those normally produced by the human pancreas.[5] They help the person digest fats, starches, and proteins.[4]
Pancreatic enzymes have been used as medications since at least the 1800s.[6] They are on the World Health Organization's List of Essential Medicines.[7] In 2021, it was the 243rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.[8][9]