S100 protein
Family of vertebrate proteins involved in cell division and inflammation / From Wikipedia, the free encyclopedia
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The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known.[1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3. They are also considered as damage-associated molecular pattern molecules (DAMPs), and knockdown of aryl hydrocarbon receptor downregulates the expression of S100 proteins in THP-1 cells.[2]
S100/ICaBP type calcium binding domain | |||||||||||
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Identifiers | |||||||||||
Symbol | S_100 | ||||||||||
Pfam | PF01023 | ||||||||||
InterPro | IPR013787 | ||||||||||
PROSITE | PDOC00275 | ||||||||||
SCOP2 | 1cnp / SCOPe / SUPFAM | ||||||||||
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