Trastuzumab
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Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer.[20][17][21][22] It is specifically used for cancer that is HER2 receptor positive.[20] It may be used by itself or together with other chemotherapy medication.[20] Trastuzumab is given by slow injection into a vein and injection just under the skin.[20][23]
Monoclonal antibody | |
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Type | Whole antibody |
Source | Humanized (from mouse) |
Target | HER2/neu |
Clinical data | |
Trade names | Herceptin, Herceptin SC, others[1] |
Biosimilars | trastuzumab-anns,[2] trastuzumab-dkst,[3] trastuzumab-dttb,[4] trastuzumab-pkrb, trastuzumab-qyyp,[5] trastuzumab-strf,[6] Hercessi,[6] Herzuma,[7] Herwenda,[8] Kanjinti,[2] Ogivri,[3][9] Ontruzant,[4] Trastucip,[10] Trazimera,[5] Tuzucip,[10] Zercepac[11] |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous, subcutaneous |
Drug class | Antineoplastic agent |
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Pharmacokinetic data | |
Metabolism | Unknown, possibly reticuloendothelial system |
Elimination half-life | 2-12 days |
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ECHA InfoCard | 100.224.377 |
Chemical and physical data | |
Formula | C6470H10012N1726O2013S42 |
Molar mass | 145531.86 g·mol−1 |
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Common side effects include fever, infection, cough, headache, trouble sleeping, and rash.[20] Other severe side effects include heart failure, allergic reactions, and lung disease.[20] Use during pregnancy may harm the baby.[12] Trastuzumab works by binding to the HER2 receptor and slowing down cell replication.[20]
Trastuzumab was approved for medical use in the United States in September 1998, and in the European Union in August 2000.[24][22] It is on the World Health Organization's List of Essential Medicines.[25]