Hemokinski (C-C motivni) ligand 21 (CCL21) jest mali citokin hemokinske porodice CC. Ovaj hemokin je poznat i kao 6Ckin (jer ima šest konzerviranih cisteinskih ostataka umjesto četiri cisteina tipska za hemokine), egzodus-2 i sekundarni limfoidni tkivni hemokin (SLC).[5][6][7]
Kratke činjenice Dostupne strukture, PDB ...
CCL21 |
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Identifikatori |
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Aliasi | CCL21 |
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Vanjski ID-jevi | OMIM: 602737 MGI: 1349183 HomoloGene: 2247 GeneCards: CCL21 |
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Ontologija gena |
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Molekularna funkcija | • cytokine activity • chemokine receptor binding • CCR7 chemokine receptor binding • chemokine activity • CCR chemokine receptor binding • GO:0001948, GO:0016582 protein binding
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Ćelijska komponenta | • extracellular region • Vanćelijsko
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Biološki proces | • negative regulation of leukocyte tethering or rolling • release of sequestered calcium ion into cytosol • positive regulation of receptor-mediated endocytosis • positive regulation of protein kinase B signaling • positive regulation of cell motility • positive regulation of actin filament polymerization • monocyte chemotaxis • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • ruffle organization • positive regulation of cell-matrix adhesion • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • T cell costimulation • cell maturation • positive regulation of JNK cascade • dendritic cell chemotaxis • negative regulation of dendritic cell dendrite assembly • positive regulation of phosphatidylinositol 3-kinase activity • Hemotaksija • response to prostaglandin E • positive regulation of dendritic cell antigen processing and presentation • dendritic cell dendrite assembly • positive regulation of pseudopodium assembly • mesangial cell-matrix adhesion • positive regulation of chemotaxis • cellular response to interleukin-1 • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • establishment of T cell polarity • positive regulation of ERK1 and ERK2 cascade • positive regulation of glycoprotein biosynthetic process • cellular response to interferon-gamma • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell chemotaxis • lymphocyte chemotaxis • positive regulation of neutrophil chemotaxis • positive regulation of cell adhesion mediated by integrin • immunological synapse formation • positive regulation of filopodium assembly • positive regulation of T cell migration • positive regulation of myeloid dendritic cell chemotaxis • positive regulation of protein kinase activity • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • negative regulation of dendritic cell apoptotic process • positive regulation of T cell chemotaxis • neutrophil chemotaxis • chemokine (C-C motif) ligand 21 signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to chemokine
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 9: 34.71 – 34.71 Mb | Chr 4: 42.77 – 42.77 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori