B-cell linker (BLNK) protein is expressed in B cells and macrophages and plays a large role in B cell receptor signaling.[5] Like all adaptor proteins, BLNK has no known intrinsic enzymatic activity.[6] Its function is to temporally and spatially coordinate and regulate downstream signaling effectors in B cell receptor (BCR) signaling, which is important in B cell development.[7] Binding of these downstream effectors is dependent on BLNK phosphorylation.[8][9] BLNK is encoded by the BLNK gene[8][10] and is also known as SLP-65,[11] BASH,[12] and BCA.[13]
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