CLDN4
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.
Quick Facts Identifiers, Aliases ...
CLDN4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, claudin 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602909; MGI: 1313314; HomoloGene: 1000; GeneCards: CLDN4; OMA:CLDN4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.[5]
Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma.[6] As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.[7]