Clotrimazole
Chemical compound / From Wikipedia, the free encyclopedia
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Clotrimazole, sold under the brand name Lotrimin, among others, is an antifungal medication.[1] It is used to treat vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and types of ringworm including athlete's foot and jock itch.[1] It can be taken by mouth or applied as a cream to the skin or in the vagina.[1]
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Trade names | Desenex, CalmYourself, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682753 |
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Routes of administration | Topical, throat lozenge |
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Bioavailability | Poor absorption by mouth (lozenge), negligible absorption through intact skin (topical) |
Protein binding | 90% |
Metabolism | Liver |
Elimination half-life | 2 hours |
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ECHA InfoCard | 100.041.589 |
Chemical and physical data | |
Formula | C22H17ClN2 |
Molar mass | 344.84 g·mol−1 |
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Melting point | 147 to 149 °C (297 to 300 °F) |
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Common side effects when taken by mouth include nausea and itchiness.[1] When applied to the skin, common side effects include redness and a burning sensation.[1] In pregnancy, use on the skin or in the vagina is believed to be safe.[1] There is no evidence of harm when used by mouth during pregnancy but this has been less well studied.[1] When used by mouth, greater care should be taken in those with liver problems.[1] It is in the azole class of medications and works by disrupting the fungal cell membrane.[1]
Clotrimazole was discovered in 1969.[2] It is on the World Health Organization's List of Essential Medicines.[3] It is available as a generic medication.[1] In 2021, it was the 273rd most commonly prescribed medication in the United States, with more than 900,000 prescriptions.[4][5]