Cortistatin (neuropeptide)
Mammalian protein found in humans / From Wikipedia, the free encyclopedia
"CORT" redirects here. For the football club, see CO Roubaix-Tourcoing.
Not to be confused with the steroids also called cortistatins (chemical structures: cortistatin A, C, and J).
Precortistatin is a protein that in humans is encoded by the CORT gene.[5][6] The 105 amino acid residue human precortistatin in turn is cleaved into cortistatin-17 and cortistatin-29. Cortistatin-17 is the only active peptide derived from the precursor.[5] Cortistatin (or more specifically cortistatin-17) is a neuropeptide that is expressed in inhibitory neurons of the cerebral cortex, and which has a strong structural similarity to somatostatin. Unlike somatostatin, when infused into the brain, it enhances slow-wave sleep. It binds to sites in the cortex, hippocampus and the amygdala.
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