Daf-2
Protein-coding gene in the species Caenorhabditis elegans / From Wikipedia, the free encyclopedia
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The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging.[1] DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens.[2] Mutations in DAF-2 and also Age-1 have been shown by Cynthia Kenyon to double the lifespan of the worms.[3][4] In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”[5]
Quick Facts abnormal dauer formation protein 2, Identifiers ...
abnormal dauer formation protein 2 | |||||||
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Identifiers | |||||||
Organism | Caenorhabditis elegans | ||||||
Symbol | daf-2 | ||||||
Entrez | 175410 | ||||||
RefSeq (mRNA) | NM_065249.5 | ||||||
RefSeq (Prot) | NP_497650.4 | ||||||
UniProt | Q968Y9 | ||||||
Other data | |||||||
Chromosome | III: 2.99 - 3.03 Mb | ||||||
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