KDM1A
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Not to be confused with LSD or Lysergic acid diethylamide.
Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene.[5] LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysine 4 (H3K4). Other reported methylated lysine substrates such as histone H3K9 and TP53 have not been biochemically validated.[6] This enzyme plays a critical role in oocyte growth, embryogenesis, hematopoiesis and tissue-specific differentiation.[7] LSD1 was the first histone demethylase to be discovered though more than 30 have since been described.[8]
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