LRP5
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene.[5][6][7] LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis pseudoglioma syndrome with a decrease in bone mass, while a gain-of-function mutation causes drastic increases in bone mass.
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