Methyldopa
Medication used to treat high blood pressure / From Wikipedia, the free encyclopedia
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Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure.[1] It is one of the preferred treatments for high blood pressure in pregnancy.[1] For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred.[1] It can be given by mouth or injection into a vein.[1] Onset of effects is around 5 hours and they last about a day.[1]
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Trade names | Aldomet, Aldoril, Dopamet, others |
Other names | L-α-Methyl-3,4-dihydroxyphenylalanine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682242 |
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Routes of administration | By mouth, intravenous |
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Bioavailability | approximately 50% |
Metabolism | Liver |
Onset of action | 4 to 6 hrs[1] |
Elimination half-life | 105 minutes |
Duration of action | 10 to 48 hrs[1] |
Excretion | Kidney for metabolites |
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ECHA InfoCard | 100.008.264 |
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Formula | C10H13NO4 |
Molar mass | 211.217 g·mol−1 |
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Common side effects include sleepiness.[1] More severe side effects include red blood cell breakdown, liver problems, and allergic reactions.[1] Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.[1]
Methyldopa was discovered in 1960.[2] It is on the World Health Organization's List of Essential Medicines.[3]