PAK1
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.[5][6]
PAK1 is one of six members of the PAK family of serine/threonine kinases which are broadly divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7).[7][8] The PAKs are evolutionarily conserved.[9] PAK1 localizes in distinct sub-cellular domains in the cytoplasm and nucleus.[10] PAK1 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects a wide variety of cellular processes such as directional motility, invasion, metastasis, growth, cell cycle progression, angiogenesis.[10][11] PAK1-signaling dependent cellular functions regulate both physiologic and disease processes, including cancer, as PAK1 is widely overexpressed and hyperstimulated in human cancer, at-large.[10][12][13]