Prednisolone
Corticosteroid medication / From Wikipedia, the free encyclopedia
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Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers.[5][6] Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, and multiple sclerosis.[6] It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops.[7][8][6] It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone.
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Trade names | Orapred, PediaPred, Millipred, others |
Other names | 11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
AHFS/Drugs.com | Monograph |
MedlinePlus | a615042 |
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Routes of administration | By mouth, intravenous, topical, eye drop |
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Elimination half-life | 2–3.5 hours[2][3][4] |
Excretion | urine |
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ECHA InfoCard | 100.000.020 |
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Formula | C21H28O5 |
Molar mass | 360.450 g·mol−1 |
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Side effects with short-term use include nausea, inability to concentrate, insomnia, or feeling tired.[5] More severe side effects include psychiatric problems, which may occur in about 5% of people.[9] Common side effects with long term use include bone loss, weakness, yeast infections, and easy bruising.[6] While short-term use in the later part of pregnancy is safe, long-term use or use in early pregnancy is occasionally associated with harm to the baby.[1] It is a glucocorticoid made from hydrocortisone (cortisol).[10]
Prednisolone was discovered and approved for medical use in 1955.[10] It is on the World Health Organization's List of Essential Medicines.[11] It is available as a generic drug.[6] In 2021, it was the 153rd most commonly prescribed medication in the United States, with more than 3 million prescriptions.[12][13]