RHEB
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.[5]
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Aliases | RHEB, RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601293; MGI: 97912; HomoloGene: 123916; GeneCards: RHEB; OMA:RHEB - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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RHEB is a recently discovered member of the Ras superfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human carcinomas.[6] For this reason, ways to inhibit RHEB to control the mTOR pathway are studied as possible treatments for uncontrollable tumor cell growth in several diseases, especially in tuberous sclerosis.[7]