Rivaroxaban
Anticoagulant drug / From Wikipedia, the free encyclopedia
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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots.[8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery.[8] It is taken by mouth.[8]
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Trade names | Xarelto, others |
Other names | BAY 59-7939 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a611049 |
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Routes of administration | By mouth |
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Bioavailability | 80–100%; Cmax = 2–4 hours (10 mg oral)[3] |
Metabolism | CYP3A4, CYP2J2 and CYP-independent mechanisms[3] |
Elimination half-life | 5–9 hours in healthy subjects aged 20 to 45[3][7] |
Excretion | 2/3 metabolized in liver and 1/3 eliminated unchanged[3] |
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ECHA InfoCard | 100.210.589 |
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Formula | C19H18ClN3O5S |
Molar mass | 435.88 g·mol−1 |
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Common side effects include bleeding.[8] Other serious side effects may include spinal hematoma and anaphylaxis.[8] It is unclear if use in pregnancy and breastfeeding is safe.[1] Compared to warfarin it has fewer interactions with other medications.[9] It works by blocking the activity of the clotting protein factor Xa.[8]
Rivaroxaban was patented in 2007 and approved for medical use in the United States in 2011.[10] In the United States, it will not be available as a generic medication until 2024.[11][12] It is on the World Health Organization's List of Essential Medicines.[13] In 2021, it was the 86th most commonly prescribed medication in the United States, with more than 8 million prescriptions.[14][15]