SRGAP2
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene.[5][6] It is involved in neuronal migration and differentiation[7] and plays a critical role in synaptic development,[8] brain mass and number of cortical neurons.[9] Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.
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SRGAP2 dimerizes through its F-BAR domain.[10] SRGAP2C, a shortened version found in early hominins and humans that only has the F-BAR domain, antagonizes its action. It slows maturation of some neurons and increases neuronal spine density.[10]