Sonidegib
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Sonidegib (INN), sold under the brand name Odomzo, is a medication used to treat cancer.[1]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Odomzo |
Other names | LDE225, erismodegib |
AHFS/Drugs.com | Monograph |
MedlinePlus | a615034 |
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Routes of administration | By mouth |
Drug class | Antineoplastic agents |
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Pharmacokinetic data | |
Bioavailability | <10% |
Protein binding | >97% |
Metabolism | Liver (CYP3A) |
Elimination half-life | ~28 days |
Excretion | Feces (~70%), urine (30%)[1] |
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Chemical and physical data | |
Formula | C26H26F3N3O3 |
Molar mass | 485.507 g·mol−1 |
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Sonidegib is Hedgehog signaling pathway inhibitor (via smoothened antagonism).[5][6]