Tadalafil
Medication used to treat erectile dysfunction / From Wikipedia, the free encyclopedia
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Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.[5][6][8] It is taken by mouth.[8] Onset is typically within half an hour and the duration is up to 36 hours.[8]
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Pronunciation | /təˈdæləfɪl/ tə-DAL-ə-fil |
Trade names | Cialis, Adcirca, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604008 |
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Routes of administration | By mouth |
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Bioavailability | Varies |
Protein binding | 94% |
Metabolism | Liver (predominantly CYP3A4) |
Metabolites | Catechol metabolite |
Onset of action | 30 minutes |
Elimination half-life | 17.5 hours |
Excretion | Feces (~61%), urine (~36%)[5] |
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ECHA InfoCard | 100.214.024 |
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Formula | C22H19N3O4 |
Molar mass | 389.411 g·mol−1 |
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Common side effects include headache, muscle pain, flushed skin, and nausea.[8] Caution is advised in those with cardiovascular disease.[8] Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss.[8] Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure.[8] Tadalafil is a PDE5 inhibitor which increases blood flow to the penis.[8] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[8]
Tadalafil was approved for medical use in the United States in 2003.[8] It is available as a generic medication.[9] In 2021, it was the 171st most commonly prescribed medication in the United States, with more than 3 million prescriptions.[10][11]