CAD protein
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) is a trifunctional multi-domain enzyme involved in the first three steps of pyrimidine biosynthesis. De-novo synthesis starts with cytosolic carbamoylphosphate synthetase II which uses glutamine, carbon dioxide and ATP. This enzyme is inhibited by uridine triphosphate (feedback inhibition).
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In 2015, the first observed pathological mutations of CAD were found in a four-year-old boy.[5]
CAD protein has been observed in the mid-piece of mammalian spermatozoa, among the mitochondria.[6]